原著論文
  • Noritada Matsuo, Yukimi Sugisaka, Shiori Aoyama, Makoto Ihara, Harue Shinoyama, Munetaka Hosokawa, Yoshinobu Kamakura, Daisuke Tanaka, Yoo Tanabe, Kazuhiko Matsuda
    Creating Pyrethrin Mimetic Phosphonates as Chemical Genetics Tools Targeting the GDSL Esterase/Lipase TcGLIP to Investigate Pyrethrin Biosynthesis
    Journal of Medicinal Chemistry 66(12) 7959-7968 2023年6月
  • Wataru Koizumi, Shuya Otsubo, Shogo Furutani, Kunihiro Niki, Koichi Takayama, Shota Fujimura, Takanobu Maekawa, Ryosuke Koyari, Makoto Ihara, Kenji Kai, Hideo Hayashi, Mohammad Shaokat Ali, Eriko Kage-Nakadai, David B. Sattelle, Kazuhiko Matsuda
    Determinants of Subtype-Selectivity of the Anthelmintic Paraherquamide A on Caenorhabditis elegans Nicotinic Acetylcholine Receptors
    Molecular Pharmacology 103(6) 299-310 2023年3月
  • Yuma Komori, Koichi Takayama, Naoki Okamoto, Masaki Kamiya, Wataru Koizumi, Makoto Ihara, Daitaro Misawa, Kotaro Kamiya, Yuto Yoshinari, Kazuki Seike, Shu Kondo, Hiromu Tanimoto, Ryusuke Niwa, David B Sattelle, Kazuhiko Matsuda
    Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids.
    PLoS Genetics 19(2) e1010522 2023年2月
  • Koichi Takayama, Ryo Ito, Haruki Yamamoto, Shuya Otsubo, Rei Matsumoto, Hisanori Ojima, Yuma Komori, Kazuhiko Matsuda, Makoto Ihara
    Effects of cofactors RIC-3, TMX3 and UNC-50, together with distinct subunit ratios on the agonist actions of imidacloprid on Drosophila melanogaster Dα1/Dβ1 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes
    Pesticide Biochemistry and Physiology 187 105177-105177 2022年10月
  • Yukimi Sugisaka, Shiori Aoyama, Konoka Kumagai, Makoto Ihara, Kazuhiko Matsuda
    TcGLIP GDSL Lipase Substrate Specificity Co-determines the Pyrethrin Composition in Tanacetum cinerariifolium.
    Journal of Agricultural and Food Chemistry 2022年7月
  • Makoto Ihara, Keiji Tanaka, Kenji Kai, Hideo Hayashi, Kazuhiko Matsuda
    Competitive chrodrimanin B interactions with rat brain GABAA receptors revealed by radioligand binding assays
    Pesticide Biochemistry and Physiology 183 105074-105074 2022年5月
  • Yuri Yoshioka, Shinichi Matsumura, Masanori Morimoto, Yuki Takemoto, Chihiro Kishi, Tatsuya Moriyama, Nobuhiro Zaima
    Inhibitory Activities of Sulfur Compounds in Garlic Essential Oil against Alzheimer’s Disease-Related Enzymes and Their Distribution in the Mouse Brain
    Journal of Agricultural and Food Chemistry 69(35) 10163-10173 2021年9月8日
  • Qiang Wang, Peng Xu, Felipe Andreazza, Yahui Liu, Yoshiko Nomura, Phil Duran, Lan Jiang, Mengli Chen, Genki Takamatsu, Makoto Ihara, Kazuhiko Matsuda, Rufus Isaacs, Eugenio E Oliveira, Yuzhe Du, Ke Dong
    Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster.
    PLoS genetics 17(7) e1009677 2021年7月
  • Feng Liu, Qiang Wang, Peng Xu, Felipe Andreazza, Wilson R Valbon, Elizabeth Bandason, Mengli Chen, Ru Yan, Bo Feng, Leticia B Smith, Jeffrey G Scott, Genki Takamatsu, Makoto Ihara, Kazuhiko Matsuda, James Klimavicz, Joel Coats, Eugenio E Oliveira, Yuzhe Du, Ke Dong
    A dual-target molecular mechanism of pyrethrum repellency against mosquitoes.
    Nature communications 12(1) 2553-2553 2021年5月
総説・著書
  • Makoto Ihara
    Ligand-gated ion channels as targets of neuroactive insecticides.
    Bioscience, biotechnology, and biochemistry 2022年2月
    • Kazuhiko Matsuda
    Chemical and biological studies of natural and synthetic products for the highly selective control of pest insect species.
    Bioscience, biotechnology, and biochemistry 2021年10月
  • Kazuhiko Matsuda
    Robust functional expression of insect nicotinic acetylcholine receptors provides new insights into neonicotinoid actions and new opportunities for pest and vector control
    Pest Management Science 77(8) 3626-3630 2021年8月
  • 松田 一彦
    昆虫のニコチン性アセチルコリン受容体の機能的発現の成功が拓く新たな世界 ネオニコチノイドの科学における画期的な発見
    化学と生物 59(6) 267-271 2021年6月
原著論文
  • A unique primary structure of RDL (resistant to dieldrin) confers resistance to GABA-gated chloride channel blockers in the two-spotted spider mite Tetranychus urticae Koch.
    Takeru Kobayashi, Susumu Hiragaki, Takeshi Suzuki, Noriaki Ochiai, Liza J Canlas, Muhammad Tufail, Naotaka Hayashi, Ahmed A M Mohamed, Mark A Dekeyser, Kazuhiko Matsuda, Makio Takeda
    Journal of neurochemistry 2020年9月
  • Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions.
    Makoto Ihara, Shogo Furutani, Sho Shigetou, Shota Shimada, Kunihiro Niki, Yuma Komori, Masaki Kamiya, Wataru Koizumi, Leo Magara, Mai Hikida, Akira Noguchi, Daiki Okuhara, Yuto Yoshinari, Shu Kondo, Hiromu Tanimoto, Ryusuke Niwa, David B Sattelle, Kazuhiko Matsuda
    Proceedings of the National Academy of Sciences of the United States of America 117(28) 16283-16291 2020年7月
  • Chemical Defense of Yacon (Smallanthus sonchifolius) Leaves against Phytophagous Insects: Insect Antifeedants from Yacon Leaf Trichomes.
    Kaisei Tsunaki, Masanori Morimoto
    Plants (Basel, Switzerland) 9(7) 2020年7月
  • Modulation by neonicotinoids of honeybee α1/chicken β2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes.
    Sho Shigetou, Shota Shimada, Ihara Makoto, Kazuhiko Matsuda
    Pesticide biochemistry and physiology 166 104545-104545 2020年6月
  • The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests.
    Shota Shimada, Masaki Kamiya, Sho Shigetou, Kakeru Tomiyama, Yuma Komori, Leo Magara, Makoto Ihara, Kazuhiko Matsuda
    Scientific reports 10(1) 7529-7529 2020年5月
  • Jasmonic acid is not a biosynthetic intermediate to produce the pyrethrolone moiety in pyrethrin II.
    Ryo Matsui, Kisumi Takiguchi, Naoshige Kuwata, Katsunari Oki, Kosaku Takahashi, Kazuhiko Matsuda, Hideyuki Matsuura
    Scientific reports 10(1) 6366-6366 2020年4月
  • Metabolome Analysis Identified Okaramines in the Soybean Rhizosphere as a Legacy of Hairy Vetch
    Nozomu Sakurai, Hossein Mardani-Korrani, Masaru Nakayasu, Kazuhiko Matsuda, Kumiko Ochiai, Masaru Kobayashi, Yusuke Tahara, Takeshi Onodera, Yuichi Aoki, Takashi Motobayashi, Masakazu Komatsuzaki, Makoto Ihara, Daisuke Shibata, Yoshiharu Fujii, Akifumi Sugiyama
    Frontiers in Genetics 11 2020年2月
  • Feeding experiment using uniformly 13C-labeled α-linolenic acid supports the involvement of the decarboxylation mechanism to produce cis-jasmone in Lasiodiplodia theobromae.
    Matsui R, Takiguchi K, Matsuda K, Takahashi K, Matsuura H
    Bioscience, biotechnology, and biochemistry 83(12) 2190-2193 2019年12月
  • Combined effects of mutations in loop C and the loop D-E-G triangle on neonicotinoid interactions with Drosophila Dα1/chicken β2 hybrid nAChRs.
    Hikida M, Shimada S, Kurata R, Shigetou S, Ihara M, Sattelle DB, Matsuda K
    Pesticide biochemistry and physiology 151 47-52 2018年10月
  • Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes
    Mengli Chen, Yuzhe Du, Guonian Zhu, Genki Takamatsu, Makoto Ihara, Kazuhiko Matsuda, Boris S. Zhorov, Ke Dong
    Pesticide Biochemistry and Physiology 151 82-89 2018年10月
  • The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease
    Shogo Furutani, Makoto Ihara, Kristin Lees, Steven D. Buckingham, Frederick A. Partridge, Jonathan A. David, Rohit Patel, Scott Warchal, Ian R. Mellor, Kazuhiko Matsuda, David B. Sattelle
    International Journal for Parasitology: Drugs and Drug Resistance 8(2) 350-360 2018年8月
  • Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.
    Ihara M, Hikida M, Matsushita H, Yamanaka K, Kishimoto Y, Kubo K, Watanabe S, Sakamoto M, Matsui K, Yamaguchi A, Okuhara D, Furutani S, Sattelle DB, Matsuda K
    British journal of pharmacology 175(11) 1999-2012 2018年6月
  • Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels
    Naoki Kato, Shogo Furutani, Junnosuke Otaka, Akira Noguchi, Kiyomi Kinugasa, Kenji Kai, Hideo Hayashi, Makoto Ihara, Shunji Takahashi, Kazuhiko Matsuda, Hiroyuki Osada
    ACS Chemical Biology 13(3) 561-566 2018年3月
  • Splice Variants of pH-Sensitive Chloride Channel Identify a Key Determinant of Ivermectin Sensitivity in the Larvae of the Silkworm Bombyx mori
    Daiki Okuhara, Shogo Furutani, Katsuhiko Ito, Makoto Ihara, Kazuhiko Matsuda
    MOLECULAR PHARMACOLOGY 92(4) 491-499 2017年10月
  • Flupyrimin: A Novel Insecticide Acting at the Nicotinic Acetylcholine Receptors
    Yasumichi Onozaki, Ryo Horikoshi, Ikuya Ohno, Shigeki Kitsuda, Kathleen A. Durkin, Tomonori Suzuki, Chiaki Asahara, Natsuko Hiroki, Rena Komabashiri, Rikako Shimizu, Shogo Furutani, Makoto Ihara, Kazuhiko Matsuda, Masaaki Mitomi, Shinzo Kagabu, Katsuhito Uomoto, Motohiro Tomizawa
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65(36) 7865-7873 2017年9月 査読有り
  • Antimalarial and Antileishmanial Activities of Phytophenolics and Their Synthetic Analogues. Morimoto M, Cantrell CL, Khan S, Tekwani BL, Duke SO Chemistry & Biodiversity 14(12) 2017年12月
  • Splice Variants of pH-Sensitive Chloride Channel Identify a Key Determinant of Ivermectin Sensitivity in the Larvae of the Silkworm Bombyx mori.
    Okuhara D, Furutani S, Ito K, Ihara M, Matsuda K
    Molecular pharmacology 92(4) 491-499 2017年10月
  • An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.
    Furutani S, Okuhara D, Hashimoto A, Ihara M, Kai K, Hayashi H, Sattelle DB, Matsuda K
    Bioscience, biotechnology, and biochemistry 81(10) 1861-1867 2017年10月
  • Flupyrimin: A Novel Insecticide Acting at the Nicotinic Acetylcholine Receptors.
    Onozaki Y, Horikoshi R, Ohno I, Kitsuda S, Durkin KA, Suzuki T, Asahara C, Hiroki N, Komabashiri R, Shimizu R, Furutani S, Ihara M, Matsuda K, Mitomi M, Kagabu S, Uomoto K, Tomizawa M
    Journal of agricultural and food chemistry 65(36) 7865-7873 2017年9月
  • Deodorizing Substance in Black Cumin (Nigella sativa L.) Seed Oil. Nakasugi T, Murakawa T, Shibuya K, Morimoto M Journal of Oleo Science 66(8) 877-882 2017年8月
  • Electrochemical Synthesis of Dihydrobenzofurans and Evaluation of Their Insect Antifeedant Activities.
    Morimoto M, Urakawa M, Komai K
    Journal of Oleo Science 66(8) 857-862 2017年8月
  • Elucidation of the biosynthetic pathway of cis-jasmone in Lasiodiplodia theobromae.
    Matsui R, Amano N, Takahashi K, Taguchi Y, Saburi W, Mori H, Kondo N, Matsuda K, Matsuura H
    Scientific reports 7(1) 6688 2017年7月
  • Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor.
    Ihara M, Hikida M, Matsushita H, Yamanaka K, Kishimoto Y, Kubo K, Watanabe S, Sakamoto M, Matsui K, Yamaguchi A, Okuhara D, Furutani S, Sattelle DB, Matsuda K
    British journal of pharmacology 2017年6月
  • Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori.
    Furutani S, Ihara M, Kai K, Tanaka K, Sattelle DB, Hayashi H, Matsuda K
    Neurotoxicology 60 240-244 2017年5月
  • Comparative ecotoxicity of imidacloprid and dinotefuran to aquatic insects in rice mesocosms
    Kobashi K, Harada T, Adachi Y, Mori M, Ihara M, Hayasaka D.
    Ecotoxicology and Environmental Safety 138 122-129 2017年
  • Ivermectin modulation of pH-sensitive chloride channels in the silkworm larvae of Bombyx mori.
    Nakatani Y, Furutani S, Ihara M, Matsuda K
    Pesticide biochemistry and physiology 126 5 2016年1月
  • Selective regulation of pyrethrin biosynthesis by the specific blend of wound induced volatiles in Tanacetum cinerariifolium.
    Sakamori K, Ono N, Ihara M, Suzuki H, Matsuura H, Tanaka K, Ohta D, Kanaya S, Matsuda K
    Plant signaling & behavior 11(4) 2016年
総説・著書
  • Neonicotinoid insecticides: Molecular targets, resistance, and toxicity
    Kazuhiko Matsuda, Makoto Ihara, David B. Sattelle
    Annual Review of Pharmacology and Toxicology 60 241-255 2020年1月
  • Okaramines and other plant fungal products as new insecticide leads.
    Matsuda K
    Current opinion in insect science 30 67-72 2018年12月
  • Neonicotinoids: molecular mechanisms of action, insights into resistance and impact on pollinators
    Makoto Ihara, Kazuhiko Matsuda
    Current Opinion in Insect Science 30 86-92 2018年12月
  • Editorial overview: Insect neuroreceptors and ion channels - roles as targets in the control of insect vectors and pests.
    Sattelle DB, Matsuda K
    Current opinion in insect science 30 iii-v 2018年12月
  • Modes of Action, Resistance and Toxicity of Insecticides Targeting Nicotinic Acetylcholine Receptors.
    Ihara M, Buckingham SD, Matsuda K, Sattelle DB
    Current medicinal chemistry 24(27) 2925-2934 2017年
  • Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors.
    Buckingham SD, Ihara M, Sattelle DB, Matsuda K
    Current medicinal chemistry 24(27) 2935-2945 2017年
原著論文
  • Synthesis of photoreactive ivermectin B1a derivatives and their actions on Haemonchus and Bombyx glutamate-gated chloride channels.
    Fuse T, Ikeda I, Kita T, Furutani S, Nakajima H, Matsuda K, Ozoe F, Ozoe Y
    Pesticide biochemistry and physiology 120 82-90 2015年5月
  • Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.
    Xu Y, Furutani S, Ihara M, Ling Y, Yang X, Kai K, Hayashi H, Matsuda K
    PloS one 10(4) 2015年
  • Furutani S, Ihara M, Nishino Y, Akamatsu M, Jones AK, Sattelle DB and Matsuda K (2014)
    Exon 3 Splicing and Mutagenesis Identify Residues Influencing Cell Surface Density of Heterologously-expressed Silkworm (Bombyx mori) Glutamate-gated Chloride Channels. Mol Pharmacol 86: 686-695..
  • Furutani S, Nakatani Y, Miura Y, Ihara M, Kai K, Hayashi H and Matsuda K (2014) GluCl a target of indole alkaloid okaramines: a 25 year enigma solved. Sci Rep 4: 6190.
  • Ihara M, Okajima T, Yamashita A, Oda T, Asano T, Matsui M, Sattelle DB and Matsuda K (2014)
    Studies on an Acetylcholine Binding Protein Identify a Basic Residue in Loop G on the β1-strand as a New Structural Determinant of Neonicotinoid Actions. Mol Pharmacol 86: 736-746.
  • Ihara M, Shimazu N, Utsunomiya M, Akamatsu M, Sattelle DB and Matsuda K (2014)
    A single amino acid polymorphism in the Drosophila melanogaster Dα1 (ALS) subunit enhances neonicotinoid efficacy at Dα-chickenβ2 hybrid nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Biosci Biotechnol Biochem 78: 543-549.
  • Ihara M, Takano Y and Yamashita A (2014)
    General flexible nature of the cytosolic regions of fungal transient receptor potential (TRP) channels, revealed by expression screening using GFP-fusion techniques. Protein Sci 23: 923-931.
  • Lees K, Jones AK, Matsuda K, Akamatsu M, Sattelle DB, Woods DJ and Bowman AS (2014)
    Functional characterisation of a nicotinic acetylcholine receptor α subunit from the brown dog tick, Rhipicephalus sanguineus. Int J Parasitol 44: 75-81.
  • Akiyoshi Y, Ju XL, Furutani S, Matsuda K and Ozoe Y (2013)
    Electrophysiological evidence for 4-isobutyl-3-isopropylbicyclophosphorothionate as a selective blocker of insect GABA-gated chloride channels. Bioorg Med Chem Lett 23: 3373-3376.
  • Ihara M, Hamamoto S, Miyanoiri Y, Takeda M, Kainosho M, Yabe I, Uozumi N and Yamashita A (2013)
    Molecular bases of multimodal regulation of a fungal transient receptor potential (TRP) channel. J Biol Chem 288: 15303-15317.
  • Kikuta Y, Yamada G, Mitsumori T, Takeuchi T, Nakayama K, Katsuda Y, Hatanaka A and Matsuda K (2013)
    Requirement of catalytic-triad and related amino acids for the acyltransferase activity of Tanacetum cinerariifolium GDSL lipase/esterase TcGLIP for ester-bond formation in pyrethrin biosynthesis. Biosci Biotechnol Biochem 77: 1822-1825.
  • Hiragaki S, Kobayashi T, Ochiai N, Toshima K, Dekeyser MA, Matsuda K and Takeda M (2012)
    A novel action of highly specific acaricide; bifenazate as a synergist for a GABA-gated chloride channel of Tetranychus urticae [Acari: Tetranychidae]. Neurotoxicology 33: 307-313.
  • Kikuta Y, Ueda H, Takahashi M, Mitsumori T, Yamada G, Sakamori K, Takeda K, Furutani S, Nakayama K, Katsuda Y, Hatanaka A and Matsuda K (2012)
    Identification and characterization of a GDSL lipase-like protein that catalyzes the ester-forming reaction for pyrethrin biosynthesis in Tanacetum cinerariifolium- a new target for plant protection. Plant Journal 71: 183-193.
  • Rahman MM, Akiyoshi Y, Furutani S, Matsuda K, Furuta K, Ikeda I and Ozoe Y (2012)
    Competitive antagonism of insect GABA receptors by iminopyridazine derivatives of GABA. Bioorg Med Chem 20: 5957-5964.
  • Ueda H, Kikuta Y and Matsuda K (2012)
    Plant communication: mediated by individual or blended VOCs? Plant Signal Behav 7: 222-226.
  • Yamaguchi M, Sawa Y, Matsuda K, Ozoe F and Ozoe Y (2012)
    Amino acid residues of both the extracellular and transmembrane domains influence binding of the antiparasitic agent milbemycin to Haemonchus contortus AVR-14B glutamate-gated chloride channels. Biochem Biophys Res Commun 419: 562-566.
  • Ihara M, Matsuura N and Yamashita A (2011)
    High-resolution Native-PAGE for membrane proteins capable of fluorescence detection and hydrodynamic state evaluation. Anal Biochem 412: 217-223.
  • Kataoka S, Furutani S, Hirata K, Hayashi H and Matsuda K (2011)
    Three austin family compounds from Penicillium brasilianum exhibit selective blocking action on cockroach nicotinic acetylcholine receptors. Neurotoxicology 32: 123-129.
  • Kikuta Y, Ueda H, Nakayama K, Katsuda Y, Ozawa R, Takabayashi J, Hatanaka A and Matsuda K (2011)
    Specific regulation of pyrethrin biosynthesis in Chrysanthemum cinerariaefolium by a blend of volatiles emitted from artificially damaged conspecific plants. Plant Cell Physiol 52: 588-596.
  • Ashikawa Y, Ihara M, Matsuura N, Fukunaga Y, Kusakabe Y and Yamashita A (2011)
    GFP-based evaluation system of recombinant expression through the secretory pathway in insect cells and its application to the extracellular domains of class C GPCRs. Protein Sci 20: 1720-1734.
  • Hirata K, Kataoka S, Furutani S, Hayashi H and Matsuda K (2011)
    A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: the first report on the mode of action. PLoS One 6: e18354.
総説・著書
  • Ihara M, Sattelle DB, Matsuda K(2015)
    Probing new components (loop G and the α-α interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors. Pesticide biochemistry and physiology 121 47-52
  • 伊原誠, 山下敦子 (2014)
    解説：TRPチャネルが多様な刺激に応答出来る仕組み. 化学と生物 52: 48－53.
  • Harris C, Matsuda K and Sattelle DB (2013)
    Dr. Kathleen Drew-Baker, "Mother of the Sea", a Manchester scientist celebrated each year for half a century in Japan. Bioessays 35: 838-839.
  • 松田一彦 (2013)
    今日の話題：天然殺虫成分ピレスリンのエステル結合形成機構の解明. 化学と生物 51: 70-73.
  • 松田　一彦(2012)
    標的受容体の構造変異に起因する殺虫剤抵抗性と展望－ネオニコチノイドの事例－ 日本農薬学会誌 37 402-404 2012年
  • Matsuda K (2012)
    Pyrethrin Biosynthesis and Its Regulation in Chrysanthemum cinerariaefolium, in Pyrethroids: From Chrysanthemum to Modern Industrial Insecticide pp 73-81.
  • 伊原誠, 山下敦子 (2011)
    クローズアップ実験法 Series218 FN-PAGE法：膜タンパク質の性状の簡便かつ迅速な解析法, in 実験医学 pp 2291-2297.
原著論文
  • Brown LA, Ihara M, Buckingham SD, Matsuda K and Sattelle DB (2006)
    Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors. J Neurochem 99: 608-615.
  • Eguchi Y, Ihara M, Ochi E, Shibata Y, Matsuda K, Fushiki S, Sugama H, Hamasaki Y, Niwa H, Wada M, Ozoe F and Ozoe Y (2006)
    Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes. Insect Mol Biol 15: 773-783.
  • Fujimoto K, Yoshimura Y, Ihara M, Matsuda K, Takeuchi Y, Aoki T and Ide T (2008)
    Cy3-3-acylcholine: a fluorescent analogue of acetylcholine for single molecule detection. Bioorg Med Chem Lett 18: 1106-1109.
  • Fukuoka K, Sawabe A, Sugimoto T, Koga M, Okuda H, Kitayama T, Shirai M, Komai K, Komemushi S and Matsuda K (2004)
    Inhibitory actions of several natural products on proliferation of rat vascular smooth muscle cells induced by Hsp60 from Chlamydia pneumoniae J138. J Agric Food Chem 52: 6326-6329.
  • Hirata K, Ishida C, Eguchi Y, Sakai K, Ozoe F, Ozoe Y and Matsuda K (2008)
    Role of a serine residue (S278) in the pore-facing region of the housefly L-glutamate-gated chloride channel in determining sensitivity to noncompetitive antagonists. Insect Mol Biol 17: 341-350.
  • Ihara M, Hirata K, Ishida C, Kagabu S and Matsuda K (2007)
    Blocking actions of alkylene-tethered bis-neonicotinoids on nicotinic acetylcholine receptors expressed by terminal abdominal ganglion neurons of Periplaneta americana. Neurosci Lett 425: 137-140.
  • Ihara M, Ishida C, Okuda H, Ozoe Y and Matsuda K (2005)
    Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and γ-hexachlorocyclohexane (γ-HCH) on gamma-aminobutyric acid- and glutamate-induced responses of American cockroach neurons. Invert Neurosci 5: 157-164.
  • Ihara M, Matsuda K, Otake M, Kuwamura M, Shimomura M, Komai K, Akamatsu M, Raymond V and Sattelle DB (2003)
    Diverse actions of neonicotinoids on chicken α7, α4β2 and Drosophila-chicken SADβ2 and ALSβ2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Neuropharmacology 45: 133-144.
  • Ihara M, Matsuda K, Shimomura M, Sattelle DB and Komai K (2004)
    Super agonist actions of clothianidin and related compounds on the SADβ2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Biosci Biotechnol Biochem 68: 761-763.
  • Ihara M, Okajima T, Yamashita A, Oda T, Hirata K, Nishiwaki H, Morimoto T, Akamatsu M, Ashikawa Y, Kuroda S, Mega R, Kuramitsu S, Sattelle DB and Matsuda K (2008)
    Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin. Invert Neurosci 8: 71-81.
  • Matsuda K, Ihara M, Nishimura K, Sattelle DB and Komai K (2001)
    Insecticidal and neural activities of candidate photoaffinity probes for neonicotinoid binding sites. Biosci Biotechnol Biochem 65: 1534-1541.
  • Matsuda K, Kanaoka S, Akamatsu M and Sattelle DB (2009)
    Diverse actions and target-site selectivity of neonicotinoids: structural insights. Mol Pharmacol 76: 1-10.
  • Matsuda K, Kikuta Y, Haba A, Nakayama K, Katsuda Y, Hatanaka A and Komai K (2005)
    Biosynthesis of pyrethrin I in seedlings of Chrysanthemum cinerariaefolium. Phytochemistry 66: 1529-1535.
  • Matsuda K, Shimomura M, Kondo Y, Ihara M, Hashigami K, Yoshida N, Raymond V, Mongan NP, Freeman JC, Komai K and Sattelle DB (2000)
    Role of loop D of the α7 nicotinic acetylcholine receptor in its interaction with the insecticide imidacloprid and related neonicotinoids. Br J Pharmacol 130: 981-986.
  • Minami K, Nakasugi T, Sun HD, Hou AJ, Ihara M, Morimoto M and Komai K (2006)
    Isolation and identification of histamine-release inhibitors from Pistacia weinmannifolia J. Pisson ex. Franch. Journal of Natural Medicines 60: 138-140.
  • Morimoto M, Fukumoto H, Hiratani M, Chavasiri W and Komai K (2006)
    Insect antifeedants, pterocarpans and pterocarpol, in heartwood of Pterocarpus macrocarpus Kruz. Biosci Biotechnol Biochem 70: 1864-1868.
  • Morimoto M, Fukumoto H, Nozoe T, Hagiwara A and Komai K (2007)
    Synthesis and insect antifeedant activity of aurones against Spodoptera litura larvae. J Agric Food Chem 55: 700-705.
  • Morimoto M, Kumeda S and Komai K (2000)
    Insect antifeedant flavonoids from Gnaphalium affine D. Don. J Agric Food Chem 48: 1888-1891.
  • Morimoto M, Matsuda K, Ohta Y, Ihara T and Komai K (2004)
    Evaluation of calcium-alginate gel as an artificial diet medium for bioassays on common cutworms. J Agric Food Chem 52: 4737-4739.
  • Morimoto M, Shimomura Y, Mizuno R and Komai K (2001)
    Electron transport inhibitor in Cyperus javanicus. Biosci Biotechnol Biochem 65: 1849-1851.
  • Morimoto M, Tanimoto K, Nakano S, Ozaki T, Nakano A and Komai K (2003) Insect antifeedant activity of flavones and chromones against Spodoptera litura. J Agric Food Chem 51: 389-393.
  • Morimoto M, Tanimoto K, Sakatani A and Komai K (2002)
    Antifeedant activity of an anthraquinone aldehyde in Galium aparine L. against Spodoptera litura F. Phytochemistry 60: 163-166.
  • Nishiwaki H, Ito K, Otsuki K, Yamamoto H, Komai K and Matsuda K (2004)
    Purification and functional characterization of insecticidal sphingomyelinase C produced by Bacillus cereus. Eur J Biochem 271: 601-606.
  • Nishiwaki H, Ito K, Shimomura M, Nakashima K and Matsuda K (2007)
    Insecticidal bacteria isolated from predatory larvae of the antlion species Myrmeleon bore (Neuroptera: Myrmeleontidae). J Invertebr Pathol 96: 80-88.
  • Nishiwaki H, Nakagawa Y, Kuwamura M, Sato K, Akamatsu M, Matsuda K, Komai K and Miyagawa H (2003)
    Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities. Pest Manag Sci 59: 1023-1030.
  • Nishiwaki H, Nakashima K, Ishida C, Kawamura T and Matsuda K (2007)
    Cloning, functional characterization, and mode of action of a novel insecticidal pore-forming toxin, sphaericolysin, produced by Bacillus sphaericus. Appl Environ Microbiol 73: 3404-3411.
  • Ohno I, Hirata K, Ishida C, Ihara M, Matsuda K and Kagabu S (2007)
    Proinsecticide candidates N-(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl derivatives of imidacloprid and 1-chlorothiazolylmethyl-2-nitroimino-imidazolidine. Bioorg Med Chem Lett 17: 4500-4503.
  • Okuda H, Sakuhana C, Yamamoto R, Kawai R, Mizukami Y and Matsuda K (2007)
    Effects of divalent cations on encapsulation and release in the GroEL-assisted folding. Biometals 20: 903-910.
  • Okuda H, Sakuhana C, Yamamoto R, Mizukami Y, Kawai R, Sumita Y, Koga M, Shirai M and Matsuda K (2008)
    The intermediate domain defines broad nucleotide selectivity for protein folding in Chlamydophila GroEL1. J Biol Chem 283: 9300-9307.
  • Raymond Delpech V, Ihara M, Coddou C, Matsuda K and Sattelle DB (2003)
    Action of nereistoxin on recombinant neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Invert Neurosci 5: 29-35.
  • Shimomura M, Okuda H, Matsuda K, Komai K, Akamatsu M and Sattelle DB (2002)
    Effects of mutations of a glutamine residue in loop D of the α7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. Br J Pharmacol 137: 162-169.
  • Shimomura M, Satoh H, Yokota M, Ihara M, Matsuda K and Sattelle DB (2005)
    Insect-vertebrate chimeric nicotinic acetylcholine receptors identify a region, loop B to the N-terminus of the Drosophila Dα2 subunit, which contributes to neonicotinoid sensitivity. Neurosci Lett 385: 168-172.
  • Shimomura M, Yokota M, Ihara M, Akamatsu M, Sattelle DB and Matsuda K (2006)
    Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site. Mol Pharmacol 70: 1255-1263.
  • Shimomura M, Yokota M, Matsuda K, Sattelle DB and Komai K (2004)
    Roles of loop C and the loop B-C interval of the nicotinic receptor α subunit in its selective interactions with imidacloprid in insects. Neurosci Lett 363: 195-198.
  • Shimomura M, Yokota M, Okumura M, Matsuda K, Akamatsu M, Sattelle DB and Komai K (2003)
    Combinatorial mutations in loops D and F strongly influence responses of the α7 nicotinic acetylcholine receptor to imidacloprid. Brain Res 991: 71-77.
  • Toshima K, Ihara M, Kanaoka S, Tarumoto K, Yamada A, Sattelle DB and Matsuda K (2008)
    Potentiating and blocking actions of neonicotinoids on the response to acetylcholine of the neuronal α4β2 nicotinic acetylcholine receptor. Journal of Pesticide Science 33: 146-151.
  • Toshima K, Kanaoka S, Yamada A, Tarumoto K, Akamatsu M, Sattelle DB and Matsuda K (2009)
    Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the α4β2 nicotinic acetylcholine receptor. Neuropharmacology 56: 264-272.
  • Yoshida N, Oeda K, Watanabe E, Mikami T, Fukita Y, Nishimura K, Komai K and Matsuda K (2001)
    Protein function. Chaperonin turned insect toxin. Nature 411: 44.
  • Yoshida N, Sugama H, Gotoh S, Matsuda K, Nishimura K and Komai K ()
    Detection of ALMB-toxin in the larval body of Myrmeleon bore by anti-N-terminus peptide antibodies. Biosci Biotechnol Biochem 63: 232-234.
総説・著書
  • Ihara M, Shimomura M, Ishida C, Nishiwaki H, Akamatsu M, Sattelle DB and Matsuda K (2007)
    A hypothesis to account for the selective and diverse actions of neonicotinoid insecticides at their molecular targets, nicotinic acetylcholine receptors: catch and release in hydrogen bond networks. Invert Neurosci 7: 47-51.
  • Ihara M (2007)
    Mechanisms of action of insecticides on ligand-gated ion channels. Journal of Pesticide Science 32: 278-280.
  • Ihara M, Matsuda K and Sattelle DB (2004)
    Actions of clothianidin and related compounds on recombinant nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes, in NEUROTOX '03 Neurotoxicological Targets from Functional Genomics and Proteomics (Beadle DJ, Mellor IR and Ussherwood PNR eds) pp 19-24, Society of Chemical Industry, London.
  • Matsuda K, Shimomura M, Ihara M, Akamatsu M and Sattelle DB (2005)
    Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies. Biosci Biotechnol Biochem 69: 1442-1452.
  • Matsuda K, Buckingham SD, Kleier D, Rauh JJ, Grauso M and Sattelle DB (2001)
    Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors. Trends Pharmacol Sci 22: 573-580.
教員の受賞
  • 2022年4月 松田一彦：近畿大学 研究奨励褒章
  • 2021年3月 松田一彦：日本農芸化学会 農芸化学会賞　「昆虫の神経イオンチャネルと除虫菊によるピレスリン生合成の制御に関する化学生物学的研究」　
  • 2018年3月 伊原誠：日本農芸化学会 農芸化学奨励賞　「イオンチャネル内蔵型受容体の高選択的リガンド認識と機能調節に関する生物有機化学研究」　
  • 2015年8月 松田一彦：ISHS Medal
  • 2010年10月 森本正則：香料・テルペンおよび精油化学に関する討論会 第8回 ベストプレゼンテーション賞 セイヨウヒキヨモギ滲出物の構成成分と機能
  • 2009年3月 松田一彦：日本農薬学会業績賞「神経系イオンチャンネルを標的とする殺虫剤の作用および選択性発現機構の研究」　
  • 2008年12月 伊原誠：日本農学進歩賞　「環境保全型農業での選択的害虫制御に関する基礎研究」
  • 2007年3月 伊原誠：日本農薬学会　奨励賞「殺虫剤のリガンド作動性イオンチャネルに対する作用機構研究」
  • 2007年3月 伊原誠：望月喜多司記念賞 奨励賞　「リガンド作動性イオンチャネルに対する殺虫剤の作用機構の選択性と多様性に関する電気生理学的研究」
  • 2003年3月 松田一彦：日本農芸化学会 農芸化学奨励賞「アリジゴクの殺虫性蛋白質および関連物質の分子構造と作用機構に関する研究」
  • 2002年 森本正則：世界アレロパシー学会 ポスター賞 Chemical defense of Cyperus spp.: the function and localization of cyperaquinones
  • 1997年3月 松田一彦：日本農薬学会 奨励賞　「ピレスロイド系殺虫剤の構造活性相関と作用機構」
学生の受賞
  • 2017年11月 野口　晃（博士前期課程1年）:JSBBA KANSAI 4th Student Forum 「Structure-activity relationship of indole alkaloids okaramines on insect glutamate-gated chloride channels」
  • 2017年8月 奥原大樹（博士前期課程2年）:The joint meeting of the 33rd annual meeting of the ISCE and the 9th meeting of the APACE International Society of Chemical Ecology　Asia-Pacific Association of Chemical Ecologists 「Ivermectin modulation of the pH-sensitive chloride channel」
原著論文
総説・著書